FRESCI / Evidence
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Horizon Europe project funded with over €4.5 million under the Marie Skłodowska-Curie Actions – Doctoral Networks (MSCA-DN). Over 48 months (2026–2029), the consortium will train 15 doctoral researchers to develop and apply next-generation human in vitro and in silico approaches for complex brain disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease.
Project resource ↗NATworks is a global, open-access database mapping companies that develop and deliver non-animal technologies and New Approach Methodologies (NAMs) for research, testing, and innovation. Promoted by Doctors Against Animal Experiments (DAAE) and developed by FRESCI, NATworks provides policymakers, industry, researchers, and investors with reliable ecosystem intelligence to support the transition toward animal-free, human-relevant science.
Project resource ↗PROJECT FOCUS: Scientific and technical support to Directorate General for Environment. Supporting the policy coordinator in scientific topics, stakeholders engagement, project management, collection, data-extract, meta-analysis and review of Directive 2010/63/EU ongoing topics. CLIENT: European Commission - Directorate General for Environment OUR ROLE: Coordinator COLLABORATORS: David Anderson; Kathy McCall; REFERENCE: DG. ENV. 090202/2025/4500084884/SER/ENV.B2
Project resource ↗PROJECT FOCUS: Exploration of Nanomaterials and Nano-enabled technology used in the Textile Industry. CLIENT: European Chemical Agency LEAD RESEARCHERS: Prof. Miguel Ángel Sogorb (Universidad Miguel Hernández, UMH) and Dr. Marco Straccia (FRESCI) UMH TEAM: Jorge Esteve, Carmen Estevan, Javier Esteban. FRESCI TEAM: Ariadna Bosch Bueno and Fabiana Solano. REFERENCE: ECHA/2024/LVP/0001
In Europe, one of the critical challenges in the healthcare system is preventing complications from medical devices such as intravenous catheters. These devices often lead to infections and thrombosis, significantly impacting patient outcomes and increasing healthcare costs. Coati-X aims to address these issues with an innovative bioactive coating made of cross-linked nanogels that can release anti-thrombotic and antibiotic drugs, simultaneously preventing infections and thrombosis. FUNDER: Funded by the European Union through the European Innovation Council - Transition programme. OUR ROLE: Project partner COORDINATOR: CMD-COAT SA PARTNERS: FRESCI by Science & Strategy SL
Project resource ↗PROJECT FOCUS: One of the main burdens for our socioeconomic system in Europe by a single disease is without question the metabolic syndrome (MbS). MbS is prominently visible in the large and ever-growing number of overweight or obese individuals. Yet, its true negative dramatic consequences among others are arteriosclerosis, hereby induced myocardial infarction, and stroke. We provide an approach for the measurement of biomarkers, using a miniatured Mid-Infrared spectrometer, a technology that is only used in laboratories due to its size and cost. The result of the project will be a wearable device to detect biomarkers non-invasively and pain-free in the interstitial fluid in the skin. FUNDER: Funded by the European Union, through EIC Pathfinder Challenge programme. OUR ROLE: Workpackage Leader COORDINATOR:Quantune Technologies GmbH PARTNERS: AIE, Joanneum Research Health, VTT Research, Radboudumc REFERENCE: Grant agreement ID 101115476
Project resource ↗PROJECT FOCUS: BimmoH (Biomedical models Hub) uses machine learning to identify and structure published scientific literature on human biology-based models for biomedical research. The resource supports discovery of human-relevant models and New Approach Methodologies (NAMs). OUR ROLE: Scientific and management coordination of the consortium developing the resource. COLLABORATORS: TenWise B.V., Ready2Use srl, AlterTox srl and EcoMole sro. REFERENCE: European Commission Joint Research Centre report JRC144237, The Biomedical models Hub (BimmoH) dataset. PUBLICATION: https://publications.jrc.ec.europa.eu/repository/handle/JRC144237
Project resource ↗PROJECT FOCUS: Exploration of Nanoparticle Release Potential and Toxicity in Products with Incorporated Nanomaterials. CLIENT: European Chemical Agency LEAD RESEARCHERS: Prof. Miguel Ángel Sogorb (Universidad Miguel Hernández, UMH) and Dr. Marco Straccia (FRESCI) UMH TEAM: Jorge Esteve and Javier Esteban FRESCI TEAM: Natalia Escacena Acosta and Fabiana Solano. REFERENCE: ECHA/2022/513
HAPLO-iPS will generate cells for therapy that are homozygous for frequent Human Leukocyte Antigen haplotypes. In other words, cells compatible with a large portion of the population. We are also creating a system to collect and keep and track of all these cell lines. The project brings together experts from many fields: stem cell research, immunology, ethics, clinical therapy, cord blood banking, regulatory affairs, and more, all working together for the future of therapy. HAPLO-iPS will make stem cell therapies faster, more affordable, and accessible to millions of patients across Europe. This will offer new hope for many conditions such as Parkinson’s disease, heart disease, and diabetes.
Project resource ↗PROJECT FOCUS: Platform deployment. OUR ROLE: Partner LEAD RESEARCHERS: Prof. Adrian Harwood, Cardiff University and Dr. Marina Mihaljevic (Johns Hopkins University) SUPPORTED BY:European Cooperation in Science and Technology REFERENCE: IG16210 PUBLICATIONS: https://www.sciencedirect.com/science/article/abs/pii/S0924977X23003966
PROJECT FOCUS: PRO-MaP aims to promote the sharing of detailed methods and reusable protocols in the life sciences. The project brings together scientists, publishers, researchers, research institutions, funders, and editors to develop recommendations and strategies for promoting open methods and protocols. PRO-MaP will work with the scientific community and stakeholder groups to facilitate their implementation. SUPPORTED BY: European Commission - Joint Research Centre OUR ROLE: Partner PROJECT LEADERS: Dr. Sofia Batista Leite (European Commission - Joint Research Centre) and Dr. Tracey L. Weissgerber (Charité - Universitätsmedizin Berlin) PUBLICATION: https://osf.io/x85gh/
Project resource ↗PROJECT FOCUS: Identification and analysis of the key traits, successful approaches and engagement strategies from online realities that can be applied to share scientific knowledge in an engaging and attractive manner. CLIENT: European Commission - Joint Research Centre OUR ROLE: Project leader COLLABORATORS: Laura Viviani and Lorenzo del Pace. REFERENCE: JRC/IPR/2021/LVP/2557
PROJECT FOCUS: Identification, analysis and reporting of legal frameworks, scientific and market trends at national and international level. Biomedical services and products' proposal development. Added value identification and SWOT. Strategic partnerships identification. CLIENT: Ajuntament de l'Hospitalet de Llobregat OUR ROLE: Project leader REFERENCE: AJT/34587/2020
Project resource ↗PROJECT FOCUS: Development of a roadmap for the viability and sustainability of the Advanced Therapies (ATMPs) platform for the Spanish region “Comunidad Valenciana” (vision and mission development, market study, resources, cost and gap analyses, marketing plan, financial plan). CLIENT: Instituto de Investigación Sanitaria La Fe (IIS La Fe) OUR ROLE: Project leader REFERENCE: Exp. 20/2020 ISSLAFE COLLABORATORS: GRADOCELL SL and Valnu Servicios de Ingenieria SL
PROJECT FOCUS: Scientific and technical support to Directorate General for Environment. Supporting the policy coordinator in scientific topics, stakeholders engagement, project management, collection, data-extract, meta-analysis and review of Directive 2010/63/EU ongoing topics. CLIENT: European Commission - Directorate General for Environment OUR ROLE: Coordinator COLLABORATORS: Mr. David Anderson; Prof. Patri Vergara, (Universitat Autónoma de Barcelona); Ms. Kathy Ryder; Ms. Laura Viviani, Mr. Lorenzo del Pace REFERENCE: DG. ENV. 07.0201/2020/834799/SER/ENV.B.2
Project resource ↗PROJECT FOCUS: Analysing the EU researchers’ view on the use of experimental models in research. OUR ROLE: Project leader COLLABORATORS: Laura Viviani and Lorenzo del Pace PUBLICATION: https://www.mdpi.com/2076-2615/12/20/2778 SUPPORTED BY: Eurogroup for Animals
PROJECT FOCUS: study to review the state-of-the-art of advanced non-animal models in use for immunogenicity testing in ATMPs. CLIENT: European Commission - Joint Research Centre OUR ROLE: Project leader COLLABORATORS: UB-CREATIO, EcoMole Ltd and Altertox sprl PUBLICATION: https://www.fre-sci.com/work.html#publications REFERENCE: JRC/IPR/2018/F.3/0035/OC - Lot 3
Project resource ↗PROJECT FOCUS: study to review the state-of-the-art of advanced non-animal models in use for Autoimmune diseases CLIENT: European Commission - Joint Research Centre OUR ROLE: Project leader COLLABORATORS: UB-CREATIO, EcoMole Ltd and Altertox sprl PUBLICATION: https://www.fre-sci.com/work.html#publications REFERENCE: JRC/IPR/2018/F.3/0035/OC - Lot 4
Project resource ↗PROJECT FOCUS: study to review the state-of-the-art of advanced non-animal models in use for Immuno-oncology. CLIENT: European Commission - Joint Research Centre OUR ROLE: Project leader COLLABORATORS: Dr. Romania, Dr. Folgiero, EcoMole Ltd and Altertox sprl PUBLICATION: https://www.fre-sci.com/work.html#publications REFERENCE: JRC/IPR/2018/F.3/0035/OC - Lot 5
Project resource ↗PROJECT FOCUS: study to review the state-of-the-art of advanced non-animal models in use for Breast Cancer. CLIENT: European Commission - Joint Research Centre OUR ROLE: Project leader COLLABORATORS: Dr. Folgiero, Dr. Romania, EcoMole Ltd and Altertox sprl PUBLICATION: https://www.fre-sci.com/work.html#publications REFERENCE: JRC/IPR/2018/F.3/0035/OC - Lot 2
Project resource ↗2026 · Technical & policy report · European Commission · JRC
This report provides the technical details of the work performed to create the BimmoH dataset, allowing full transparency on the article selection process. It covers the methodological approach, going from data preparation to the identification of the best machine learning approaches for detecting the use of human biology-based models in biomedical research articles and indexing them, as well as the validation of the dataset.
DOI: 10.2760/0117069
Read the source ↗2025 · Digital resource · European Commission · JRC
BimmoH is the largest dataset containing scientific article references making use of human biology-based models. It consolidates information on a wide range of models based on human biology, including organ-on-a-chip technologies, 3D cell cultures, and computational models.
Read the source ↗2025 · Technical & policy report · BioMed21 Collaboration
Leveraging non-animal methods to position Europe as global leader in health research.
Read the source ↗2026 · Peer-reviewed article · Alternatives to Laboratory Animals
Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies
DOI: 10.1177/02611929251398821
Read the source ↗2025 · Technical & policy report · ECHA · European Observatory for Nanomaterials
The study, published by the European Observatory for Nanomaterials (EUON), analysed the applications of nano-enabled textiles and their presence on the EU and global market. The results point to the need to step up research efforts and policy development in order to ensure the safety of these innovative materials.
Read the source ↗2025 · Digital resource · Doctors Against Animal Experiments · FRESCI
The NATworks platform offers a compact overview of companies with their products, offers and services for your human-relevant research questions.
Read the source ↗2025 · White paper · FRESCI · CM4Cure
Safer devices for kidney disease and cancer patients.
DOI: 10.13140/RG.2.2.19848.69128
Read the source ↗2024 · Peer-reviewed article · PLOS Biology
Promoting reusable and open methods and protocols (PRO-MaP) can improve methodological reporting in the life sciences
DOI: 10.1371/journal.pbio.3002835
Read the source ↗2024 · Technical & policy report · European Commission · JRC
Promoting reusable and open methods and protocols (PRO-MaP): recommendations to improve methodological clarity in life sciences publications.
Read the source ↗2025 · Peer-reviewed article · NAM Journal
Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report
DOI: 10.1016/j.namj.2025.100023
Read the source ↗2023 · Peer-reviewed article · International Journal of Molecular Sciences
Cell Therapy of Vascular and Neuropathic Complications of Diabetes: Can We Avoid Limb Amputation?
DOI: 10.3390/ijms242417512
Read the source ↗2025 · Peer-reviewed article · Clinical Transplantation
Clinical Practice Recommendations on the Effect of COVID-19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients
DOI: 10.1111/ctr.70100
Read the source ↗2024 · Technical & policy report · ECHA · European Observatory for Nanomaterials
Review of the potential for release of nanoparticles from products and articles with embedded nanomaterials and the possible toxicity of the released nanoparticles
Read the source ↗2022 · Peer-reviewed article · International Journal of Environmental Research and Public Health
Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform
DOI: 10.3390/ijerph192315828
Read the source ↗2022 · Peer-reviewed article · Animals
Researchers and Their Experimental Models: A Pilot Survey in the Context of the European Union Health and Life Science Research
DOI: 10.3390/ani12202778
Read the source ↗2020 · Peer-reviewed article · Frontiers in Cellular Neuroscience
Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases?
DOI: 10.3389/fncel.2020.00250
Read the source ↗2020 · Technical & policy report · European Commission · JRC
Advanced non-animal models in biomedical research - Breast cancer: executive summary
Read the source ↗2021 · Technical & policy report · European Commission · JRC
Advanced non-animal models in biomedical research - Immuno-oncology: executive summary
Read the source ↗2022 · Technical & policy report · European Commission · JRC
Advanced non-animal models in biomedical research: Immunogenicity testing for advanced therapy medicinal products
Read the source ↗2022 · Technical & policy report · European Commission · JRC
Advanced non-animal models in biomedical research - Autoimmune diseases: Executive summary
Read the source ↗2021 · White paper · FRESCI
The Value of Bioclusters during COVID-19 Pandemics
DOI: 10.13140/RG.2.2.12493.56808
Read the source ↗2026 · Peer-reviewed article · Journal of Translational Medicine
DOI: 10.1186/s12967-026-08604-1
Read the source ↗2026 · Peer-reviewed article · iScience
DOI: 10.1016/j.isci.2026.116633
Read the source ↗2026 · Peer-reviewed article · Trends in Biotechnology
DOI: 10.1016/j.tibtech.2026.08.005
Read the source ↗